Description
CD3 is a multimeric protein complex, which is composed of four distinct chains (CD3γ, CD3δ and two CD3ε). CD3 complex serves as a T-cell co-receptor that associates non-covalently with the T cell receptor (TCR) [1]. CD3 is expressed in almost all T cell lineages, which make it useful marker for T cells. T cells exhibit multiple functions including cell-mediated cytotoxicity, promotion of antibody production by B cells, and immune regulation. CD3+ T cells can be divided into several subsets. CD4+ helper T cell, CD8+ cytotoxic T cell and NK cells are the three major subsets. T cells have been widely used in research fields including immunology, infectious diseases, cancer therapy, etc. [2]
iXCells Biotechnologies offers CD3+ Pan T Cells from the human peripheral blood of individual healthy donors using negative immunomagnetic selection. These cells are untouched by the separation process and ready for downstream usage. > 86% of the cells are CD3+ as shown by flow cytometric analysis.
Figure 1. Flow cytometric analysis showed that >86% of the cells are CD3+.
Product Details
| Tissue | Normal human peripheral blood |
| Package Size | 20.0 x 106 cells/vial, 40.0 x 106 cells/vial |
| Passage Number | P0 |
| Shipped | Cryopreserved |
| Storage | Liquid nitrogen |
| Growth Properties | Suspension |
| Media | Blood Cell Culture Medium (Cat# MD-0007) |
Reference
[1] Smith-Garvin JE, Koretzky GA and Jordan MS. T cell activation. Annual Review of Immunology 2009:27: 591-619. [2] Vigneron N. Human Tumor Antigens and Cancer Immunotherapy. Biomed Res Int. 2015.
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