Human Bronchial Smooth Muscle Cells (HBSMC)

产品代码: 10HU-194
产品类别: 人源原代细胞

现有规格: Cryopreserved, 0.5 million cells/vial

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产品代码: 10HU-194

人源支气管平滑肌细胞

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产品规格

选择产品规格: Cryopreserved, 0.5 million cells/vial

01 / PRODUCT INFORMATION

产品介绍

Product Description Airway smooth muscle is fundamental for maintaining airway tone. The specialized ultrastructural features and regulatory mechanisms of airway smooth muscle are vital for normal airway function. Patients with respiratory disorders, such as severe asthma, exhibit the distinguishing feature of increased bronchial smooth muscle mass. The increase in smooth muscle mass is related either to abnormal bronchial smooth muscle cell (BSMC) proliferation or the accumulation of contractile protein. Smooth muscle cell proliferation is an important component of airway remodeling in asthma and is consequently a target for the development of novel anti-asthma agents. Airway smooth muscle cells express CT-1 [1] and release GM-CSF, RANTES and IL-8 in vitro [2]. In order to develop therapies for asthma, researchers have utilized BSMC to elucidate the cellular and molecular mechanisms underlying BSMC proliferation. 查看原资料图片 ↗ Figure 1. Human Bronchial Smooth Muscle Cells (HBSMC) (phase contrast). iXCells Biotechnologies provides high quality Human Bronchial Smooth Muscle Cells (HBSMC), which are isolated from human bronchi and bronchioles and cryopreserved at P1, with >0.5 million cells in each vial. HBSMC express α-smooth muscle actin and desmin and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fung. HBSMC can further expand in Smooth Muscle Cell Growth Medium (Cat # MD-0034) under the condition suggested by iXCells Biotechnologies. Product Details

Tissue	Human bronchia and bronchioles
Package Size	0.5 million cells/vial
Passage Number	P1
Shipped	Cryopreserved
Storage	Liquid nitrogen
Growth Properties	Adherent
Media	Smooth Muscle Cell Growth Medium (Cat # MD-0034)

References [1] Zhou, D., Zheng, X., Wang, L., Stelmack, G., Halayko, A. J., Dorscheid, D. and Bai, T. R. (2003) Expression and effects of cardiotrophin-1 (CT-1) in human airway smooth muscle cells. British Journal of Pharmacology 140:1237-1244. [2] Oltmanns, U., Issa, R., Sukkar, M. B., John, M. and Chung, K. F. (2003) Role of c-jun N-terminal kinase in the induced release of GM-CSF, RANTES and IL-8 from human airway smooth muscle cells. British Journal of Pharmacology 139:1228-1234.

02 / PRODUCT INFORMATION

产品说明

Product Description

Airway smooth muscle is fundamental for maintaining airway tone. The specialized ultrastructural features and regulatory mechanisms of airway smooth muscle are vital for normal airway function. Patients with respiratory disorders, such as severe asthma, exhibit the distinguishing feature of increased bronchial smooth muscle mass. The increase in smooth muscle mass is related either to abnormal bronchial smooth muscle cell (BSMC) proliferation or the accumulation of contractile protein. Smooth muscle cell proliferation is an important component of airway remodeling in asthma and is consequently a target for the development of novel anti-asthma agents. Airway smooth muscle cells express CT-1 [1] and release GM-CSF, RANTES and IL-8 in vitro [2]. In order to develop therapies for asthma, researchers have utilized BSMC to elucidate the cellular and molecular mechanisms underlying BSMC proliferation.

查看原资料图片 ↗

Figure 1.Human Bronchial Smooth Muscle Cells (HBSMC) (phase contrast).

iXCells Biotechnologies provides high quality Human Bronchial Smooth Muscle Cells (HBSMC), which are isolated from human bronchi and bronchioles and cryopreserved at P1, with >0.5 million cells in each vial. HBSMC express α-smooth muscle actin and desmin and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fung. HBSMC can further expand in Smooth Muscle Cell Growth Medium (Cat# MD-0034) under the condition suggested by iXCells Biotechnologies.

Product Details

Tissue	Human bronchia and bronchioles
Package Size	0.5 million cells/vial
Passage Number	P1
Shipped	Cryopreserved
Storage	Liquid nitrogen
Growth Properties	Adherent
Media	Smooth Muscle Cell Growth Medium (Cat# MD-0034)

References

[1] Zhou, D., Zheng, X., Wang, L., Stelmack, G., Halayko, A. J., Dorscheid, D. and Bai, T. R. (2003) Expression and effects of cardiotrophin-1 (CT-1) in human airway smooth muscle cells. British Journal of Pharmacology 140:1237-1244.

[2] Oltmanns, U., Issa, R., Sukkar, M. B., John, M. and Chung, K. F. (2003) Role of c-jun N-terminal kinase in the induced release of GM-CSF, RANTES and IL-8 from human airway smooth muscle cells. British Journal of Pharmacology 139:1228-1234.

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