Human Aortic Smooth Muscle Cells (HASMC)

Product Description

Smooth muscle cells (SMC) are primary contributors to the development of arterial disease [1]. The ability of vascular SMC to switch to a proliferative phenotype is one of the main factors in the development and progression of vascular disease. Recent studies have demonstrated that SMC express calcium channels [2], ICAM-1, and VCAM-1. The expression of ICAM-1 and VCAM-1 on SMC may contribute to the inflammatory reaction in the vascular wall and may actively be involved in the progression of vascular disease [3]. Vascular SMC in culture play an important role in vascular disease research and can be used to identify new therapeutic targets to treat arterial disease.

iXCells Biotechnologies provides high quality Human Aortic Smooth Muscle Cells (HASMC), which are isolated from human aorta and cryopreserved at P1, with >0.5 million cells in each vial. HASMC express α-smooth muscle actin and desmin and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fung. HASMC can further expand in Smooth Muscle Cell Growth Medium (Cat# MD-0034) under the condition suggested by iXCells Biotechnologies.

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References

[1] Schwartz, S. M., Campbell, G. R., Campbell, J. H. (1986) Replication of smooth muscle cells in vascular disease. Circ. Res. 58:427-444.

[2] Fan, Q. I., Vanderpool, K., Marsh, J. D. (2002) A 27 bp cis-acting sequence is essential for L-type calcium channel alpha(1C) subunit expression in vascular smooth muscle cells. Biochim Biophys Acta. 1577:401-11.

[3] Braun, M., Pietsch, P., Schror, K., Baumann, G., Felix, S. B. (1999) Cellular adhesion molecules on vascular smooth muscle cells. Cardiovasc. Res. 41:395-401.

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[1] Zhou, D., Zheng, X., Wang, L., Stelmack, G., Halayko, A. J., Dorscheid, D. and Bai, T. R. (2003) Expression and effects of cardiotrophin-1 (CT-1) in human airway smooth muscle cells. British Journal of Pharmacology 140:1237-1244.

[2] Oltmanns, U., Issa, R., Sukkar, M. B., John, M. and Chung, K. F. (2003) Role of c-jun N-terminal kinase in the induced release of GM-CSF, RANTES and IL-8 from human airway smooth muscle cells. British Journal of Pharmacology 139:1228-1234.