Description
Product Description
Excitation and inhibition are the two basic interactions between neurons, which utilize glutamate and γ-aminobutyric acid (GABA) as the major neurotransmitters for excitatory and inhibitory signals, respectively. Abnormal GABAergic neuron function has been associated with multiple neurodevelopmental and neurodegenerative disorders.
iXCells™ Cortical GABAergic Neurons show high neuronal purity (>90% Tuj1 positive cells) and express typical marker GABA (Figure 1 and Figure 2) after culturing in the Cortical Neuron Maintenance Medium (Cat# MD-0093) for 5 days.
iXCells also provide customized differentiation service with your own iPS cell lines. Please contact us at orders@amogene.com for more details.
Figure 1. Phase contrast image of iPSC-GABAergic neurons cultured in the Cortical Neuron Maintenance Medium (Cat# MD-0093) for 5 days.
Figure 2. The cryopreserved GABAergic neurons were recovered and seeded on Matrigel-coated 96-well plate and cultured in the Cortical Neuron Maintenance Medium (Cat# MD-0093) for 5 days. The cells were fixed and stained with anti-GABA (red) and anti-TUJ1 (green) antibodies.
Product Details
| Tissue Origin | Human iPSC-derived GABAergic Neurons |
| Package Size | 1.0 million cells/vial (cryopreserved) 4.0 million cells/vial (cryopreserved) |
| Shipped | Frozen on dry ice |
| Media | Cortical Neuron Maintenance Medium (Cat# MD-0093) |
[1] Yang N, Chanda S et al. (2017). “Generation of pure GABAergic neurons by transcription factor programming”. Nat Methods. 14(6):621-628.
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