10HU-007
Human Adipose Derived Stem Cells (ADSCs, Type 2 Diabetes)
Cryopreserved, 0.5 million cells/vial
产品与技术资料CELL CULTURE / PRODUCT
Human Cardiac Microvascular Endothelial Cells (HCMEC)
- 产品代码
- 10HU-052
- 产品类别
- 人源原代细胞
- 现有规格
- Cryopreserved, 0.5 million cells/vial
原产品简介与规格资料
产品代码: 10HU-052
人源心脏微血管内皮细胞
价格有浮动，详情咨询 (+86) 15750729215
产品规格
选择产品规格:
Cryopreserved, 0.5 million cells/vial
01 / PRODUCT INFORMATION
产品介绍
Product Description
The endothelial cells modulate vascular tone by release of several endothelium-derived contracting and relaxing factors, by regulation and degradation of vasoactive peptides, and by enzymes located on the Cardiac microvascular endothelial cells (HCMEC) play important roles in myocardial function. HCMEC regulate vascular tone by releasing and degrading endothelium-derived vasoactive factors, and modulating the local levels of vasoconstrictors and vasodilators through their enzymatic activities. Many of these substances can also modify myocardial contractile behavior [1]. Furthermore, microvasculature has been shown to participate in the regulation of leukocyte recruitment, inflammation, and angiogenesis. They are also capable of trans-differentiating into myofibroblasts, suggesting a role in aberrant accumulation of matrix and fibrotic disorders [2]. HCMEC cultures provide an invaluable tool for understanding HCMEC physiological and pathophysiological relevance in cardiac function and disease.
iXCells Biotechnologies provides high quality HCMEC, which are isolated from human heart and cryopreserved at P2, with >0.5 million cells in each vial. These HCMEC express vWF/Factor VIII, CD31 (PECAM) (Figure 1), and Dil-Ac-LDL by uptake. They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand for in Endothelial Cell Growth Medium (Cat# MD-0010) under the condition suggested by iXCells Biotechnologies.
查看原资料图片：HCMEC ↗
Figure 1. (A) Immunofluorescence staining for vWF (red) and CD31 (green). (B) Flow analysis showed that 85.09% of the cells are positive for CD31.
Product Details
References [1] Yang, Z. K., Draper, N. J. and Shah, A. M. (1999) Ca2+-independent inhibition of myocardial contraction by coronary effluent of hypoxic rat hearts. Am. J. Physiol. 276:H623-632. [2] Paulus, W. J., P. J. Vantrimpont, and A. M. Shah. Paracrine coronary endothelial control of left ventricular function in humans. Circulation 92: 2119-2162, 1995 [3] Shah, A. M. (1996) Paracrine modulation of heart cell function by endothelial cells. Cardiovasc Res, 31(6):847-67.
Product Details
| Tissue | Human heart |
| Package Size | 0.5 million cells/vial |
| Passage Number | P2 |
| Shipped | Cryopreserved |
| Storage | Liquid nitrogen |
| Growth Properties | Adherent |
| Media | Endothelial Cell Growth Medium (Cat# MD-0010) |
References [1] Yang, Z. K., Draper, N. J. and Shah, A. M. (1999) Ca2+-independent inhibition of myocardial contraction by coronary effluent of hypoxic rat hearts. Am. J. Physiol. 276:H623-632. [2] Paulus, W. J., P. J. Vantrimpont, and A. M. Shah. Paracrine coronary endothelial control of left ventricular function in humans. Circulation 92: 2119-2162, 1995 [3] Shah, A. M. (1996) Paracrine modulation of heart cell function by endothelial cells. Cardiovasc Res, 31(6):847-67.
02 / PRODUCT INFORMATION
产品说明
Product Description
The endothelial cells modulate vascular tone by release of several endothelium-derived contracting and relaxing factors, by regulation and degradation of vasoactive peptides, and by enzymes located on the Cardiac microvascular endothelial cells (HCMEC) play important roles in myocardial function. HCMEC regulate vascular tone by releasing and degrading endothelium-derived vasoactive factors, and modulating the local levels of vasoconstrictors and vasodilators through their enzymatic activities. Many of these substances can also modify myocardial contractile behavior [1]. Furthermore, microvasculature has been shown to participate in the regulation of leukocyte recruitment, inflammation, and angiogenesis. They are also capable of trans-differentiating into myofibroblasts, suggesting a role in aberrant accumulation of matrix and fibrotic disorders [2]. HCMEC cultures provide an invaluable tool for understanding HCMEC physiological and pathophysiological relevance in cardiac function and disease.
iXCells Biotechnologies provides high quality HCMEC, which are isolated from human heart and cryopreserved at P2, with >0.5 million cells in each vial. These HCMEC express vWF/Factor VIII, CD31 (PECAM) (Figure 1), and Dil-Ac-LDL by uptake. They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand for in Endothelial Cell Growth Media under the condition suggested by iXCells Biotechnologies.
Figure 1. (A) Immunofluorescence staining for vWF (red) and CD31 (green).(B) Flow analysis showed that 85.09% of the cells are positive for CD31.
Product Details
| Tissue | Human heart |
| Package Size | 0.5 millioncells/vial |
| Passage Number | P2 |
| Shipped | Cryopreserved |
| Storage | Liquid nitrogen |
| Growth Properties | Adherent |
| Media | Endothelial Cell Growth Media |
References
[1] Yang, Z. K., Draper, N. J. and Shah, A. M. (1999) Ca2+-independent inhibition of myocardial contraction by coronary effluent of hypoxic rat hearts. Am. J. Physiol. 276:H623-632.
[2] Paulus, W. J., P. J. Vantrimpont, and A. M. Shah. Paracrine coronary endothelial control of left ventricular function in humans. Circulation 92: 2119-2162, 1995
[3] Shah, A. M. (1996) Paracrine modulation of heart cell function by endothelial cells. Cardiovasc Res, 31(6):847-67.
03 / PRODUCT INFORMATION
资料下载
04 / PRODUCT INFORMATION
文献与引用
Yang, K., Fan, M., Wang, X., Xu, J., Wang, Y., Gill, P. S., Ha, T., Liu, L., Hall, J. V., Williams, D. L., & Li, C. (2022). Lactate induces vascular permeability via disruption of VE-cadherin in endothelial cells during sepsis. Science Advances, 8(17). https://doi.org/10.1126/sciadv.abm8965 -- Learn More
Chou, C., Hung, C., Liao, C., Wei, L., Chen, C., Shun, C., . . . Lin, Y. (2018). Il-6 trans-signalling contributes to aldosterone-induced cardiac fibrosis. Cardiovascular Research, 114(5), 690-702. doi:10.1093/cvr/cvy013 -- Learn More
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