Human Brain Vascular Pericytes (HBVP)

Product Description

Pericytes are contractile cells that wrap around the endothelial cells of capillary and venules throughout the body ^[1]. Pericytes are embedded in basement membrane, where they communicate with endothelial cells by means of direct physical contact and paracrine signaling ^[2]. In the brain, pericytes help sustain the blood-brain barriers, which regulate capillary blood flow, the clearance and phagocytosis of cellular debris and the permeability of the blood-brain barrier. Pericytes deficiency in the central nervous system can cause the blood-brain barrier breakdown, leading to neurodegenerative diseases.

iXCells Biotechnologies provides high quality Human Brain Vascular Pericytes (HBVP), which are isolated from human brain and cryopreserved at P2, with >0.5 million cells in each vial. These HBVP are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. They can further expand for no more than 3 passages in Human Pericyte Growth Medium (Cat# MD-0030) under the condition suggested by iXCells Biotechnologies. Additional expansion is not recommended, because the purity of pericyte population may decrease.

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Figure 1. Human Brain Vascular Pericytes (HBVP). (A) Phase contrast image of HBVP. (B) Immunofluorescence staining with antibody against Anti-alpha smooth muscle Actin (α-SMA).

Product Details

References

[1]  Birbrair etc and Osvaldo. Role fo pericytes in skeletal muscle regeneration and fat accumulation. Stem Cell and Development 2013, 22(16): 2298-2314.

[2]  Bergers G and Song S. The role of pericytes in blood-vessel formation and maintenance. Neuro-Oncology 2005, 7(4): 452-464.

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