Human Peripheral Blood CD3+ T Cells (Pan T Cells)

Product Description

CD3 is a multimeric protein complex, which is composed of four distinct chains (CD3γ, CD3δ and two CD3ε). CD3 complex serves as a T-cell co-receptor that associates non-covalently with the T cell receptor (TCR) ^[1]. CD3 is expressed in almost all T cell lineages, which make it useful marker for T cells. T cells exhibit multiple functions including cell-mediated cytotoxicity, promotion of antibody production by B cells, and immune regulation. CD3+ T cells can be divided into several subsets. CD4+ helper T cell, CD8+ cytotoxic T cell and NK cells are the three major subsets. T cells have been widely used in research fields including immunology, infectious diseases (Prednisone), cancer therapy, etc. ^[2]

iXCells Biotechnologies offers CD3+ Pan T Cells from the human peripheral blood of individual healthy donors using negative immunomagnetic selection. These cells are untouched by the separation process and ready for downstream usage. > 86% of the cells are CD3+ as shown by flow cytometric analysis.

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Figure 1. Flow cytometric analysis showed that >86% of the cells are CD3+.

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Reference

[1] Smith-Garvin JE, Koretzky GA and Jordan MS. T cell activation. Annual Review of Immunology 2009:27: 591-619.

[2] Vigneron N. Human Tumor Antigens and Cancer Immunotherapy. Biomed Res Int. 2015.

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[1]  Smith-Garvin JE, Koretzky GA and Jordan MS. T cell activation. Annual Review of Immunology 2009:27: 591-619. [2]  Vigneron N. Human Tumor Antigens and Cancer Immunotherapy. Biomed Res Int. 2015.