10HU-007
Human Adipose Derived Stem Cells (ADSCs, Type 2 Diabetes)
Cryopreserved, 0.5 million cells/vial
产品与技术资料CELL CULTURE / PRODUCT
人脂肪干细胞
Human Adipose Derived Stem Cells (hADSC, Normal)
- 产品代码
- 10HU-001
- 产品类别
- 人源原代细胞
所选规格会带入产品咨询，供货情况另行确认。
原产品简介与规格资料
产品代码:10HU-001
人脂肪干细胞产品规格
选择产品规格:
Cryopreserved, 0.5 million cells/vial
Cryopreserved, 1.0 million cells/vial
01 / PRODUCT INFORMATION
产品说明
Product Description
Human Adipose-Derived Stem cells (ADSCs) are isolated from human lipoaspirate tissue collected during elective surgical liposuction procedures. ADSCs are available for normal donors, patients with Type 1 Diabetes, Type 2 Diabetes, or Obesity (BMI>30). It has been shown that the ADSCs demonstrate very similar phenotypic and functional characteristics to that of bone marrow-derived mesenchymal stem cells. Thousands of articles have been published on ADSCs using a variety of terminology, including preadipocytes, adipose-derived mesenchymal stem cells (AD-MSCs), adipose MSCs (AMSCs), adipose-derived adult stem (ADAS) cells, and adipose stromal/stem cells (ASCs). Normal human ADSCs have been reported to differentiate into many different lineages including chondrogenic, osteogenic, adipogenic and neural. And have been applied in studies include stem cell differentiation, regenerative medicine [1], and cell therapy [2].
iXCells Biotechnologies offers normal human adipose-derived stem cells (hADSC) from adipose tissues from single donor, and cryopreserved at passage 1. hADSC are positive for CD29, CD44, CD73, CD90, CD105, and negative for CD14, CD31, CD45 (Figure 1). hADSC can be in vitro differentiated into adipocytes and osteoblasts (Figure 2 and 3) using Adipocyte Differentiation Medium (Cat# MD-0005) and Osteogenic Differentiation Medium (Cat# MD-0006), separately. hADSC can be further expanded for 3-4 passages using Adipose-Derived Stem Cell Growth Medium (Cat# MD-0003). These cells are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi.
Figure 1. Immunostaining of cell surface markers of human ADSC.
查看原资料图片：Adipogenic Induction ↗
Figure 2. Human ADSC adipocyte differentiation (Day 14 post adipogenic induction).
查看原资料图片：Osteogenic induction ↗
Figure 3. Human ADSC osteogenic induction (Day 24 post osteogenic induction). Alizarin Red S staining of osteoblasts. The extracellular calcium deposit was stained in bright orange-red color.
Product Details
| Tissue | Human adipose tissue from liposuction procedures |
| Package Size | 0.5 million cells/vial; 1.0 million cells/vial |
| Passage Number | P1 |
| Shipped | Cryopreserved |
| Storage | Liquid nitrogen |
| Growth Properties | Adherent |
| Media | Adipose-Derived Stem Cell Growth Medium (Cat# MD-0003) Adipocyte Differentiation Medium (Cat# MD-0005) Osteogenic Differentiation Medium (Cat# MD-0006) |
References
[1] Harasymiak-Krzyzanowska I et al. Adipose tissue-derived stem cells show considerable promise for regenerative medicine applications. Cell Mol Biol Lett. 2013; 18(4): 479-493.
[2] Bertheuil N, et al and Tarte K. Adipose-derived stromal cells: history, isolation, immunomodulatory properties and clinical perspective. Ann Chir Plast Esthet. 2015;60(2): 94-102.
02 / PRODUCT INFORMATION
资料下载
03 / PRODUCT INFORMATION
文献与引用
Bioz 实时文献组件 · 可在组件内筛选和滚动浏览；无法载入时可在 Bioz 打开。
Zhu, L., Feng, Z., Shu, X., Gao, Q., Wu, J., Du, Z., Li, R., Wang, L., Chen, N., Li, Y., Luo, M., & Wu, J. (2021). In situ transplantation of adipose-derived stem cells via photoactivation improves glucose metabolism in obese mice. Stem Cell Research & Therapy, 12(1). https://doi.org/10.1186/s13287-021-02494-4 -- Learn More
Millender, Jayla, "Impact of Angiogenic and Osteogenic Factors in the Presence of Biodegradable Piezoelectric Films" (2021). Honors Scholar Theses. 815. https://opencommons.uconn.edu/srhonors_theses/815 -- Learn More
Laiva, A. L., O’Brien, F. J., & Keogh, M. B. (2021). SDF-1α Gene-Activated Collagen Scaffold RESTORES pro-angiogenic wound HEALING features in Human Diabetic Adipose-derived stem cells. Biomedicines, 9(2), 160. doi:10.3390/biomedicines9020160 -- Learn More
Suku, M., Laiva, A. L., O’Brien, F. J., & Keogh, M. B. (2021). Anti-ageing protein β-klotho rejuvenates diabetic stem cells for improved gene-activated scaffold based wound healing. Journal of Personalized Medicine, 11(1), 4. doi:10.3390/jpm11010004 -- Learn More
Das, R., Curry, E. J., Le, T. T., Awale, G., Liu, Y., Li, S., . . . Nguyen, T. D. (2020). Biodegradable nanofiber bone-tissue scaffold as remotely-controlled and self-powering electrical stimulator. Nano Energy, 76, 105028. doi:10.1016/j.nanoen.2020.105028 -- Learn More
Srifa, W., Kosaric, N., Amorin, A., Jadi, O., Park, Y., Mantri, S., . . . Porteus, M. (2020). Cas9-aav6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice. Nature Communications, 11(1). doi:10.1038/s41467-020-16065-3 -- Learn More
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