Description
p-Tau 217: A Key Biomarker in Alzheimer’s Disease
Threonine 217 is one of the critical phosphorylation sites in tau, making p-Tau 217 a significant biomarker for Alzheimer’s disease. Research shows that p-Tau 217 levels in cerebrospinal fluid (CSF) and blood are significantly elevated in patients with Alzheimer’s, even in the early stages, indicating its potential as a valuable diagnostic and prognostic tool. Furthermore, studies have shown that p-Tau 217 can help differentiate Alzheimer’s disease from other forms of dementia, such as Lewy body dementia and frontotemporal dementia.
Applications and Intended Use
The Quanterix Simoa® ALZpath p-Tau 217 assay is validated for use in discovery and diagnostic research applications. The Simoa® ALZpath p-Tau 217 assay targets the proline-rich region of the Tau protein, which is highly conserved amongst the tau isoforms.
- Research on Neurodegenerative Diseases: By measuring phosphorylated tau protein levels in the blood, researchers can gain insights into the role of p-Tau 217 in the disease process and develop new diagnostics and neuro-prognostics for these debilitating diseases.
- Drug Discovery: Identify and screen promising drug candidates for further development and testing.
- Biomarker Discovery and Validation: Researchers can use the Simoa® ALZpath p-Tau 217 assay to validate emerging biomarkers, providing researchers with a reliable and accurate tool for biomarker discovery workflows.
Compatible Instruments
The ALZpath p-Tau 217 assay is available for use on the Quanterix HD-X™ Automated Immunoassay Analyzer and SR-X™ Biomarker Detection System.
Simoa® ALZpath p-Tau-217 Advantage PLUS Assay Performance (HD-X)
Analytical LLOQ: 0.00326 pg/mL
Functional LLOQ: 0.00978 pg/mL
Functional ULOQ: 30 pg/mL
LOD: 0.0008 pg/mL; range 0.0003-0.0021 pg/mL
Dynamic Range: 0-30 pg/mL
Tests per kit: 96
Simoa® ALZpath p-Tau-217 Advantage PLUS Assay Performance (SR-X)
Functional LLOQ: 0.0129 pg/mL
LOD: 0.0004 pg/mL
Kit Contents
The assay kit includes all necessary reagents and controls to perform 96 tests, making it easy to use and compatible with various sample types.
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