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Neurology 4-Plex D (BD-Tau, NfL, GFAP*, UCH-L1*)
The Simoa® Neurology 4-Plex D (N4PD) Advantage PLUS measures four key neurology biomarkers in blood and cerebrospinal fluid (CSF) samples: neurofilament light (NfL), glial fibrillary acidic protein (GFAP*), ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1*), and the novel biomarker brain-derived Tau…
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Neurology 4-Plex D (BD-Tau, NfL, GFAP*, UCH-L1*)
Product Number 104822
The Simoa® Neurology 4-Plex D (N4PD) Advantage PLUS measures four key neurology biomarkers in blood and cerebrospinal fluid (CSF) samples: neurofilament light (NfL), glial fibrillary acidic protein (GFAP*), ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1*), and the novel biomarker brain-derived Tau (BD-Tau). These biomarkers play established and emerging roles in the identification, risk assessment and management of diseases across the neurodegenerative spectrum and brain injury. The N4PD Advantage PLUS biomarkers are also available in single-plex or other multiplex formats as part of the Simoa® neurology Advantage PLUS assay family, with comparable performance for individual markers shared across the assay family. By measuring multiple biomarkers simultaneously, N4PD provides ultra-sensitivity, sample efficiency, and broader insights, with added brain specificity from BD-Tau, all within the ease of a single assay workflow and a single sample input. *UCH-L1™ and Banyan GFAP™ are registered trademarks of Banyan Biomarkers
01 / DESCRIPTION
产品说明
Neurology 4-Plex D (BD-Tau, NfL, GFAP*, UCH-L1*)
Product Number 104822
The Simoa® Neurology 4-Plex D (N4PD) Advantage PLUS measures four key neurology biomarkers in blood and cerebrospinal fluid (CSF) samples: neurofilament light (NfL), glial fibrillary acidic protein (GFAP*), ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1*), and the novel biomarker brain-derived Tau (BD-Tau).
These biomarkers play established and emerging roles in the identification, risk assessment and management of diseases across the neurodegenerative spectrum and brain injury. The N4PD Advantage PLUS biomarkers are also available in single-plex or other multiplex formats as part of the Simoa® neurology Advantage PLUS assay family, with comparable performance for individual markers shared across the assay family.
By measuring multiple biomarkers simultaneously, N4PD provides ultra-sensitivity, sample efficiency, and broader insights, with added brain specificity from BD-Tau, all within the ease of a single assay workflow and a single sample input.
*UCH-L1™ and Banyan GFAP™ are registered trademarks of Banyan Biomarkers
Key features of the Simoa® Neurology 4-Plex D Advantage PLUS Assay
- First multiplex assay solution for simultaneous measurement of BD-Tau with NfL, GFAP*, and UCH-L1*
- Ultra-sensitive quantification of 4 key neuro biomarkers at sub-picogram levels
- Workflow efficiency with full automation enabled on the HD-X
- Enhanced accuracy for longitudinal and large-scale studies powered by Advantage PLUS
Applications and Intended Use
Simoa® N4PD Advantage PLUS is a digital immunoassay for the quantitative determination of BD-Tau, NfL, BD-Tau, GFAP*, and UCH-L1* concentrations in human serum, EDTA plasma, and CSF samples.
Assay Specifications
- Compatible instruments: HD-X
- Analytical Lower Limit of Quantification (LLOQ): 0.259-3.48 pg/mL
- Lower Limit of Detection (LOD): 0.029-0.577 pg/mL
- Dynamic range: varies by marker and by sample type
(For detailed specifications, please refer to the N4PD Advantage PLUS Datasheet)
Kit Contents
The assay kit includes all necessary reagents and controls to perform 96 tests.
Related Resources
Uncover Insights with BD-Tau and Key Neurology Biomarkers
BD-Tau as a Plasma Biomarker of Neurodegeneration in Alzheimer’s Disease
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