TGFβ

TGFβ

Human TGFβ exists as three isoforms (1,2,3), that are 70-80% homologous; the Simoa Human TGFβ assay recognizes all 3 isoforms. As part of a Kinase complex, TGFβ initiates a signal cascade that upregulates target gene expression. Target genes activated by this cascade impact a wide range of functions including cell invasion, environmental modification, differentiation, proliferation, and immune cell activation. Modification of the normal TGFβ pathway is associated with cancer development. Because TGFβ is secreted by most cell types, dysfunction is associated with many types of cancer. In many such cancers, malignancy correlates with an increased expression of TGFβ and a progressive loss of TGFβ-mediated growth inhibition.