IL-17A

Interleukin 17A (IL-17A) is disulfide-linked homodimeric cytokine of 155 amino acids (molecular weight 35kDa) and a member of an IL-17 family of related cytokines (IL-17B through IL-17F). All IL-17 cytokines have a similar protein structure, and no sequence similarity to any other cytokines. These cytokines are well conserved in mammals, with significant sequence conservation between the human and mouse homologs. A major role of IL-17A is its involvement in inducing and mediating proinflammatory responses. It acts as a potent mediator in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to interferon gamma. IL-17A is produced by T-helper cells and is induced by IL–23 which results in destructive tissue damage in delayed-type reactions. IL-17 induces the production of many other synergistic cytokines, including GM-CSF, IL-6, IL-1b, and TNFa. The IL-17 family has been linked to many immune/autoimmune related diseases including rheumatoid arthritis, asthma, lupus, allograft rejection, anti-tumor immunity and recently psoriasis.

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IL-17A in Neurodegeneration

In neurodegenerative diseases, IL-17A is thought to contribute to disease progression by promoting inflammation and neurotoxicity. For example, IL-17A levels are elevated in the brains of patients with Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis (ALS). In addition, studies have shown that blocking IL-17A signaling can protect against neurodegeneration in animal models of these diseases.

Researchers are currently investigating the role of IL-17A in neurodegeneration and developing new ways to block IL-17A signaling as a potential treatment for these diseases. For example, some clinical trials are currently underway to evaluate the safety and efficacy of IL-17A inhibitors in patients with multiple sclerosis and ALS.

Applications and Intended Use

The IL-17A assay is a digital immunoassay for the quantitative determination of IL-17A in serum and plasma.

Compatible Instruments

• Advantage Plus: HD-X/SR-X
• Advantage: HD-1/HD-X/SR-X

Kit Contents

The assay kit includes all necessary reagents and controls to perform 96 tests, making it easy to use and compatible with various sample types.

Related Resources

• Simoa® IL-17A Fact Sheet