{"id":2788,"date":"2025-07-02T11:09:48","date_gmt":"2025-07-02T03:09:48","guid":{"rendered":"https:\/\/biomobio.com\/?post_type=product&p=2788"},"modified":"2025-12-23T16:08:58","modified_gmt":"2025-12-23T08:08:58","slug":"human-intestinal-microvascular-endothelial-cells-himec","status":"publish","type":"product","link":"https:\/\/biomobio.com\/?product=human-intestinal-microvascular-endothelial-cells-himec","title":{"rendered":"Human Intestinal Microvascular Endothelial Cells (HIMEC)"},"content":{"rendered":"

Product Description<\/strong><\/p>\n

Endothelial cells lining the microvasculature are known to play a critical \u201cgatekeeper\u201d role in the inflammatory process through their ability to recruit circulating immune cells into tissues and foci of inflammation. Studies show that intestinal microvascular endothelial cells (IMEC) exhibit a strong immune response to LPS challenge and play a critical regulatory role in gut inflammation [1]. Pharmacological inhibition of NOS in activated HIMEC\u00a0resulted in a significant increase in leukocyte binding [2]. Gene expression profile studies revealed that intestinal endothelial cells express biotinidase, which is involved in biotin recycling [3]. HIMEC cultures have enabled scientists to perform systematic analyses of cytokine profiles with regard to mRNA expression and protein secretion, and to compare these data with cytokine profiles from other endothelial cells.<\/p>\n

iXCells Biotechnologies provides high quality HIMEC, which are isolated from human intestinal tissue and cryopreserved at P1, with >0.5 million cells in each vial. HIMEC express vWF\/Factor VIII, CD31 (PECAM), and Dil-Ac-LDL by uptake. They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand for 10 population doublings in\u00a0Endothelial Cell Growth Medium (Cat# MD-0010)<\/a>\u00a0under the condition suggested by iXCells Biotechnologies.<\/p>\n

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Product Details<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n
\u00a0\u00a0Tissue<\/strong><\/td>\n\u00a0 Human\u00a0intestinal tissue<\/td>\n<\/tr>\n
\u00a0 Package Size<\/strong><\/td>\n\u00a0 0.5 million\u00a0cells\/vial<\/td>\n<\/tr>\n
\u00a0 Passage Number<\/strong><\/td>\n\u00a0 P1<\/td>\n<\/tr>\n
\u00a0 Shipped<\/strong><\/td>\n\u00a0 Cryopreserved<\/td>\n<\/tr>\n
\u00a0 Storage<\/strong><\/td>\n\u00a0 Liquid nitrogen<\/td>\n<\/tr>\n
\u00a0 Growth Properties<\/strong><\/td>\n\u00a0 Adherent<\/td>\n<\/tr>\n
\u00a0 Media<\/strong><\/td>\n\u00a0\u00a0Endothelial Cell Growth Medium (Cat# MD-0010)<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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References<\/strong><\/p>\n[1]. Ogawa, H., Rafiee, P., Heidemann, J., Fisher, P. J., Johnson, N. A., Otterson, M. F., Kalyanaraman, B., Pritchard, K. A. Jr., Binion, D. G. (2003) Mechanisms of endotoxin tolerance in human intestinal microvascular endothelial cells. J Immunol. 170(12):5956-64.
\n[2]. Binion, D. G., Fu, S., Ramanujam, K. S., Chai, Y. C., Dweik, R. A., Drazba, J. A., Wade, J. G., Ziats, N. P., Erzurum, S. C. and Wilson, K. T. (1998) iNOS xpression in human intestinal microvascular endothelial cells inhibits leukocyte adhesion. Am. J. Physiol. 275:G592-603.
\n[3]. Chi, J-T, Chang, H. Y., Haraldsen, G., Jahnsen, F. L., Troyanskaya, O. G., Chang, D. S., Wang, Z., Rockson, S. G., van de Rijn, M., Botstein, D. and Brown, P. O. (2003) Endothelial cell diversity revealed by global expression profiling. PNAS 100(19):10623-10628.<\/p>\n","protected":false},"excerpt":{"rendered":"

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\u4ea7\u54c1\u4ee3\u7801:<\/strong>\u00a010HU-065<\/div>\n
\u4eba\u80a0\u9053\u5fae\u8840\u7ba1\u5185\u76ae\u7ec6\u80de<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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Call for Price:<\/div>\n
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\u4ea7\u54c1\u89c4\u683c<\/h2>\n
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\u9009\u62e9\u4ea7\u54c1\u89c4\u683c:<\/strong>
\nCryopreserved, 0.5 million cells\/vial<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"featured_media":3295,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"product_cat":[83],"product_tag":[92,136],"class_list":{"0":"post-2788","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-83","7":"product_tag-cryopreserved","8":"product_tag-human-intestinal-microvascular-endothelial-cells","10":"first","11":"instock","12":"shipping-taxable","13":"purchasable","14":"product-type-simple"},"acf":[],"yoast_head":"\nHuman Intestinal Microvascular Endothelial Cells (HIMEC) - \u4f70\u9ed8\u751f\u7269<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomobio.com\/?product=human-intestinal-microvascular-endothelial-cells-himec\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Human Intestinal Microvascular Endothelial Cells (HIMEC) - 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