{"id":2861,"date":"2025-07-07T10:32:23","date_gmt":"2025-07-07T02:32:23","guid":{"rendered":"https:\/\/biomobio.com\/?p=2861"},"modified":"2025-07-07T10:32:48","modified_gmt":"2025-07-07T02:32:48","slug":"chai%e2%80%912","status":"publish","type":"post","link":"https:\/\/biomobio.com\/?p=2861","title":{"rendered":"Chai\u20112\uff1a\u5b9e\u73b0 24 \u5b54\u677f\u201c\u96f6\u5c04\u51fb\u201d\u6297\u4f53\u8bbe\u8ba1\uff0c\u547d\u4e2d\u7387\u8fbe\u4e24\u4f4d\u6570"},"content":{"rendered":"\t\t
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\u6d1b\u6749\u77f6 \u2014 2025 \u5e74 7 \u6708 7 \u65e5<\/strong> \u2014\u2014 \u751f\u7269\u8bbe\u8ba1 AI \u521d\u521b\u516c\u53f8 Chai Discovery \u4eca\u65e5\u5bf9\u5916\u516c\u5e03\u5176\u6700\u65b0\u4e00\u4ee3\u5206\u5b50\u751f\u6210\u6a21\u578b Chai\u20112<\/a><\/strong>\uff0c\u5ba3\u544a\u6380\u8d77\u5206\u5b50\u5de5\u7a0b\u65b0\u7eaa\u5143\u3002\u8be5\u6a21\u578b\u53ef\u5728\u6807\u51c6 24 \u5b54\u677f\u5b9e\u9a8c\u6761\u4ef6\u4e0b\uff0c\u9488\u5bf9\u672a\u77e5\u9776\u6807\u76f4\u63a5\u8bbe\u8ba1\u5168\u65b0\u6297\u4f53\uff0c\u53ea\u9700\u7b5b\u9009\u5c11\u91cf\u5019\u9009\u5206\u5b50\uff08\u226420 \u4e2a \/ \u9776\u6807\uff09\uff0c\u5373\u53ef\u5b9e\u73b0 16\u201320\u202f%<\/strong> \u7684\u5b9e\u9a8c\u547d\u4e2d\u7387\uff0c\u5e76\u5728 52 \u4e2a\u4ee5\u524d\u65e0\u5df2\u77e5\u6297\u4f53\u7684\u86cb\u767d\u9776\u70b9\u4e2d\uff0c\u6210\u529f\u8bc6\u522b\u51fa\u81f3\u5c11\u4e00\u4e2a\u53ef\u884c binder \u7684\u6bd4\u7387\u8fbe 50\u202f%<\/strong><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\ud83d\udd2c \u6280\u672f\u7a81\u7834\uff1a\u4ece\u201c\u6d77\u91cf\u7b5b\u9009\u201d\u5230\u201c\u96f6\u5c04\u51fb\u201d\u8bbe\u8ba1<\/span><\/strong><\/h2>

\u6297\u4f53\u53d1\u73b0\u9ad8\u5ea6\u4f9d\u8d56\u52a8\u7269\u514d\u75ab\u6216\u5e9e\u5927\u6587\u5e93\u7b5b\u9009\uff0c\u8017\u65f6\u8017\u8d44\uff0c\u4e14\u5bf9\u65b0\u5174\u6216\u96be\u6253\u9776\u70b9\u5e38\u9677\u5165\u74f6\u9888\uff1b\u65e9\u671f AI \u65b9\u6cd5\u867d\u6709\u6539\u8fdb\uff0c\u4f46\u4f9d\u65e7\u9700\u7b5b\u9009\u6570\u767e\u4e07\u5e8f\u5217\u3002\u672c\u6b21\u63a8\u51fa\u7684 Chai\u20112\uff0c\u901a\u8fc7\u591a\u6a21\u6001\u751f\u6210\u67b6\u6784\u2014\u2014\u6574\u5408\u539f\u5b50\u7ea7\u7ed3\u6784\u9884\u6d4b\u4e0e\u6297\u4f53\u5e8f\u5217\u751f\u6210\uff0c\u9996\u6b21\u5b9e\u73b0\u5b8c\u5168\u96f6\u5c04\u51fb\u8bbe\u8ba1\uff0c\u547d\u4e2d\u7387\u76f8\u6bd4\u6b64\u524d\u4f4e\u4e8e 0.1% \u7684\u5e38\u89c4\u7b97\u6cd5\u63d0\u9ad8 100 \u500d\u4ee5\u4e0a<\/strong><\/span>\u3002\u76f8\u6bd4\u4f20\u7edf\u9700\u8981\u6570\u6708\u751a\u81f3\u6570\u5e74\u5b9e\u9a8c\u5468\u671f\uff0cChai\u20112 \u53ef\u5b9e\u73b0\u4ece\u8bbe\u8ba1\u5230\u9274\u5b9a \u4e24\u5468\u5185<\/strong> \u5b8c\u6210 \u2728<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\u2699\ufe0f \u5173\u952e\u6570\u636e\uff1a\u5b9e\u9a8c\u9a8c\u8bc1\u6210\u679c\u4eae\u773c<\/strong><\/span><\/h2>

  • \u5b9e\u9a8c\u4e2d\uff0cChai\u20112 \u9488\u5bf9 52<\/strong> \u4e2a\u5168\u65b0\u6297\u539f\u9776\u70b9\u8bbe\u8ba1\u6297\u4f53\uff0c\u5171\u68c0\u9a8c\u7ea6 1,040<\/strong> \u4e2a\u5019\u9009\u5206\u5b50\uff1b<\/span><\/p><\/li>

  • \u603b\u4f53\u547d\u4e2d\u7387\u8fbe 16\u202f%<\/strong>\uff0c\u4e14\u534a\u6570\u9776\u70b9\u83b7\u5f97\u81f3\u5c11\u4e00\u4e2a binders\uff1b<\/span><\/p><\/li>

  • \u5728\u5c0f\u86cb\u767d\u2013\u7eb3\u7c73\u86cb\u767d\uff08miniprotein\uff09\u8bbe\u8ba1\u4e2d\uff0cChai\u20112 \u5b9e\u73b0\u9ad8\u8fbe 68\u202f%<\/strong> \u7684\u547d\u4e2d\u7387\uff0c\u90e8\u5206 binder \u8fbe\u5230\u76ae\u6469\u5c14\u7ea7\u4eb2\u548c\u529b\u6c34\u5e73\u3002<\/span><\/p><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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    \n\n52 novel antigens targeted by Chai-2. Blue boxes indicate targets with at least one successful binder out of \u226420 assayed designs, representing 50% of the tested targets.\n\n<\/em>\n<\/p>\n<\/blockquote>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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    \ud83e\uddec \u591a\u6a21\u6001\u529b\u91cf\uff1a\u7cbe\u786e\u63a7\u5236\u539f\u5b50\u7ea7\u7ed3\u6784\u4e0e\u9776\u5411\u8868\u4f4d<\/strong><\/span><\/h2>

    Chai\u20112 \u7684\u6838\u5fc3\u4f18\u52bf\u5728\u4e8e\u5176 \u591a\u6a21\u6001\u751f\u6210\u67b6\u6784<\/strong>\uff1a<\/p>

    • \u80fd\u6839\u636e\u6297\u539f\u7ed3\u6784\u4e0e\u8868\u4f4d\u4f4d\u70b9\uff0c\u4ece\u96f6\u5f00\u59cb\u8bbe\u8ba1\u6297\u4f53 CDR \u533a\u5e8f\u5217\uff1b<\/span><\/p><\/li>

    • \u53ef\u751f\u6210\u6db5\u76d6 scFv\u3001\u7eb3\u7c73\u6297\u4f53\uff08VHH\uff09\u3001\u5c0f\u86cb\u767d\u8f7d\u4f53\u7b49\u591a\u79cd\u683c\u5f0f\u7684 binder\uff1b<\/span><\/p><\/li>

    • \u8bbe\u8ba1\u7ed3\u679c\u65b0\u9896\u591a\u6837\uff0c\u5e8f\u5217\u4e0e\u5df2\u77e5\u6297\u4f53\u76f8\u4f3c\u5ea6\u6781\u4f4e\uff1b<\/p><\/li>

    • \u652f\u6301\u4ea4\u53c9\u53cd\u5e94\uff08cross\u2011reactivity\uff09\u548c\u591a\u7279\u5f02\u6027 binder \u7684\u5b9a\u5411\u8bbe\u8ba1\uff1b<\/span><\/p><\/li>

    • \u53ef\u4ee5\u5bf9\u914d\u4f53\u3001\u5171\u4ef7\u4fee\u9970\u548c PTMs \u7b49\u590d\u6742\u8868\u4f4d\u8fdb\u884c\u5efa\u6a21\uff0c\u6269\u5c55\u81f3\u5b8f\u73af\u3001\u9176\u3001\u5c0f\u5206\u5b50\u7b49\u66f4\u590d\u6742\u5206\u5b50\u5de5\u7a0b<\/span>\u3002<\/p><\/li><\/ul>

      \"\"<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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      \u2b50 \u5c55\u671b\u672a\u6765\uff1a\u4ece\u7ecf\u9a8c\u9a71\u52a8\u5230\u7f16\u7a0b\u8bbe\u8ba1<\/strong><\/span><\/h2>\n

      Chai Discovery \u56e2\u961f\u8868\u793a\uff0cChai\u20112 \u7684\u6210\u529f\u6807\u5fd7\u7740\u6297\u4f53\u7814\u53d1\u5c06\u7531\u4f20\u7edf\u7ecf\u9a8c\u9a71\u52a8\u9010\u6b65\u8fc7\u6e21\u4e3a\u201c\u7f16\u7a0b\u9a71\u52a8<\/strong>\u201d\u5f62\u6001\u3002\u672a\u6765\uff0c\u501f\u52a9\u8fd9\u79cd\u539f\u5b50\u7ea7\u6a21\u62df\u5e73\u53f0\uff0c\u5148\u7aef\u836f\u7269\u5206\u5b50\u7684\u53d1\u73b0\u4e0e\u4f18\u5316\u5c06\u66f4\u5feb\u3001\u66f4\u7cbe\u786e\u3001\u66f4\u53ef\u63a7\u2014\u2014\u751a\u81f3\u6709\u671b\u5b9e\u73b0\u5355\u8f6e IND\u202f\u5019\u9009\u836f\u7269\u8bbe\u8ba1<\/strong>\uff0c\u5f7b\u5e95\u98a0\u8986\u4f20\u7edf\u836f\u7269\u7814\u53d1\u6d41\u7a0b<\/span>\u3002<\/p>\n\n\n

      \n\n

      \ud83d\udca1 \u83b7\u5f97\u65b9\u5f0f\u4e0e\u8d23\u4efb\u90e8\u7f72<\/strong><\/span><\/h2>\n

      \u76ee\u524d\uff0cChai Discovery \u5df2\u5f00\u59cb\u5411\u5b66\u672f\u673a\u6784\u4e0e\u884c\u4e1a\u5408\u4f5c\u4f19\u4f34\u63d0\u4f9b Chai\u20112 \u65e9\u671f\u4f7f\u7528\u6743\u9650\u3002\u516c\u53f8\u4e5f\u5df2\u53d1\u5e03\u201cResponsible Deployment\u201d\u653f\u7b56\uff0c\u4f18\u5148\u652f\u6301\u5bf9\u4eba\u7c7b\u5065\u5eb7\u4e0e\u793e\u4f1a\u516c\u76ca\u6709\u663e\u8457\u8d21\u732e\u7684\u9879\u76ee\uff0c\u5e76\u786e\u4fdd\u5206\u5b50\u5b89\u5168\u53ca\u751f\u7269\u5b89\u5168\u98ce\u9669\u53ef\u63a7<\/span>\u3002<\/p>\n\n\n

      \n\n

      \ud83d\udd17 \u5173\u4e8e Chai Discovery<\/strong><\/span><\/h2>\n

      \u6210\u7acb\u4e8e 2024 \u5e74\u521d\u7684 Chai Discovery\uff0c\u81f4\u529b\u4e8e\u4ee5 AI \u4e3a\u6838\u5fc3\u9a71\u52a8\u529b\uff0c\u6253\u9020\u539f\u5b50\u7ea7\u7cbe\u5bc6\u7684\u5168\u8c31\u751f\u7269\u8bbe\u8ba1\u5e73\u53f0\uff0c\u4ece\u5206\u5b50\u9884\u6d4b\u5230\u751f\u6210\u3001\u4ece\u7ed3\u6784\u518d\u5230\u5b9e\u9a8c\u9a8c\u8bc1\uff0c\u5b9e\u73b0\u201c\u751f\u7269\u5b66\u4ece\u79d1\u5b66\u8f6c\u5316\u4e3a\u5de5\u7a0b\u201d\u7684\u4f7f\u547d\u3002\u5176\u521b\u59cb\u56e2\u961f\u7531 OpenAI\u3001Meta FAIR\u3001Google \u7b49\u77e5\u540d\u7814\u7a76\u673a\u6784\u80cc\u666f\u7684\u79d1\u5b66\u5bb6\u7ec4\u6210\uff1b\u9996\u6b3e\u6a21\u578b Chai\u20111 \u4e8e 2024 \u5e74 9 \u6708\u53d1\u51fa\uff0c\u8868\u73b0\u5df2\u8d85\u8d8a AlphaFold\u20113<\/span>\u3002<\/p>\n\n\"\"\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

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