{"id":1988,"date":"2025-04-27T14:20:22","date_gmt":"2025-04-27T06:20:22","guid":{"rendered":"https:\/\/biomobio.com\/?p=1988"},"modified":"2025-04-30T19:56:05","modified_gmt":"2025-04-30T11:56:05","slug":"%e3%80%8colink-reveal%e3%80%8d-%e6%96%87%e7%8c%ae%e8%a7%a3%e8%af%bb-%e4%b8%a4%e7%a7%8d%e4%ba%b2%e5%92%8c%e5%8a%9b%e5%b9%b3%e5%8f%b0%e5%af%b94000%e5%90%8d%e4%b8%ad%e5%9b%bd%e6%88%90%e5%b9%b4%e4%ba%ba","status":"publish","type":"post","link":"https:\/\/biomobio.com\/?p=1988","title":{"rendered":"\u300cOlink Reveal\u300d- \u4e24\u79cd\u4eb2\u548c\u529b\u5e73\u53f0\u5bf94000\u540d\u4e2d\u56fd\u6210\u5e74\u4eba2168\u79cd\u8840\u6d46\u86cb\u767d\u7684\u6bd4\u8f83\u7814\u7a76"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1988\" class=\"elementor elementor-1988\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f9ec3f3 e-flex e-con-boxed e-con e-parent\" data-id=\"f9ec3f3\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-afc5be0 elementor-widget elementor-widget-heading\" data-id=\"afc5be0\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u300cOlink Reveal\u300d- \u6587\u732e\u89e3\u8bfb: \u4e24\u79cd\u4eb2\u548c\u529b\u5e73\u53f0\u5bf94000\u540d\u4e2d\u56fd\u6210\u5e74\u4eba2168\u79cd\u8840\u6d46\u86cb\u767d\u7684\u6bd4\u8f83\u7814\u7a76<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-da8ae1b elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"da8ae1b\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2f41073 elementor-widget elementor-widget-text-editor\" data-id=\"2f41073\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3 style=\"text-align: left;\"><strong><span style=\"color: #000000;\">\u4e00\u3001\u7814\u7a76\u80cc\u666f\u4e0e\u6838\u5fc3\u95ee\u9898<\/span><\/strong><\/h3><p><span style=\"color: #000000;\">\u86cb\u767d\u8d28\u7ec4\u5b66\u4f5c\u4e3a\u63ed\u793a\u4eba\u7c7b\u751f\u7269\u5b66\u673a\u5236\u548c\u836f\u7269\u5f00\u53d1\u7684\u91cd\u8981\u5de5\u5177\uff0c\u8fd1\u5e74\u6765\u5728\u5927\u89c4\u6a21\u4eba\u7fa4\u548c\u4e34\u5e8a\u7814\u7a76\u4e2d\u5f97\u5230\u4e86\u5e7f\u6cdb\u5e94\u7528\u3002\u9ad8\u901a\u91cf\u86cb\u767d\u8d28\u68c0\u6d4b\u6280\u672f\u4e3b\u8981\u5305\u62ec\u8d28\u8c31\u6cd5\u548c\u4eb2\u548c\u6027\u6355\u83b7\u6cd5\uff0c\u540e\u8005\u4ee5Olink\uff08\u6297\u4f53\u6cd5\uff09\u548cSomaScan\uff08\u9002\u914d\u4f53\u6cd5\uff09\u4e3a\u4ee3\u8868\uff0c\u80fd\u591f\u5728\u5355\u6b21\u5b9e\u9a8c\u4e2d\u68c0\u6d4b\u6570\u5343\u79cd\u86cb\u767d\u3002\u7136\u800c\uff0c\u4e0d\u540c\u5e73\u53f0\u4e4b\u95f4\u7684\u68c0\u6d4b\u7ed3\u679c\u4e00\u81f4\u6027\u3001\u9057\u4f20\u5b66\u548c\u8868\u578b\u5173\u8054\u7684\u53ef\u6bd4\u6027\uff0c\u4ee5\u53ca\u5728\u75be\u75c5\u98ce\u9669\u9884\u6d4b\u4e2d\u7684\u5b9e\u9645\u5e94\u7528\u4ef7\u503c\uff0c\u59cb\u7ec8\u662f\u4e1a\u754c\u5173\u6ce8\u7684\u6838\u5fc3\u95ee\u9898\u3002<\/span><\/p><p><span style=\"color: #000000;\">\u672c\u7814\u7a76\u9488\u5bf9\u4e0a\u8ff0\u95ee\u9898\uff0c\u9996\u6b21\u5728\u4e2d\u56fd\u4eba\u7fa4\u4e2d\uff0c\u5229\u7528Olink Explore 3072\u548cSomaScan v4.1\u5e73\u53f0\uff0c\u5bf93976\u540d\u4e2d\u56fd\u6210\u5e74\u4eba\uff082168\u79cd\u86cb\u767d\uff09\u8fdb\u884c\u4e86\u5e73\u884c\u68c0\u6d4b\u548c\u7cfb\u7edf\u6bd4\u8f83\uff0c\u65e8\u5728\uff1a<\/span><\/p><ol><li><span style=\"color: #000000;\">\u8bc4\u4f30\u4e24\u5e73\u53f0\u86cb\u767d\u6c34\u5e73\u7684\u76f8\u5173\u6027\u53ca\u5f71\u54cd\u56e0\u7d20\uff1b<\/span><\/li><li><span style=\"color: #000000;\">\u6bd4\u8f83\u4e24\u5e73\u53f0\u5728\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u5206\u6790\uff08GWAS\uff09\u4e2d\u53d1\u73b0\u7684pQTL\uff08\u86cb\u767d\u8d28\u6570\u91cf\u6027\u72b6\u4f4d\u70b9\uff09\uff1b<\/span><\/li><li><span style=\"color: #000000;\">\u6bd4\u8f83\u86cb\u767d\u4e0e\u8868\u578b\uff08\u5982BMI\uff09\u53ca\u75be\u75c5\uff08\u5982\u7f3a\u8840\u6027\u5fc3\u810f\u75c5\uff0cIHD\uff09\u98ce\u9669\u7684\u5173\u8054\u4e00\u81f4\u6027\uff1b<\/span><\/li><li><span style=\"color: #000000;\">\u5206\u6790\u86cb\u767d\u7ec4\u6570\u636e\u5728IHD\u98ce\u9669\u9884\u6d4b\u4e2d\u7684\u589e\u76ca\u4ef7\u503c\u3002<\/span><\/li><\/ol>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-db5023c elementor-widget elementor-widget-image\" data-id=\"db5023c\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"640\" height=\"488\" src=\"https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/1.jpg\" class=\"attachment-large size-large wp-image-1995\" alt=\"\" srcset=\"https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/1.jpg 810w, https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/1-600x457.jpg 600w, https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/1-300x229.jpg 300w, https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/1-768x585.jpg 768w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><strong>Fig. 1 | Summary of study design, analytical approaches, and key findings. <\/strong>Main analyses were conducted on 1694 one-to-one matched Olink-SomaScan reagent pairs in 3976 CKB participants. Results were corrected for multiple testing using false discovery rate within each platform. Risk predictionmodels for IHDwere built using conventional risk factors (age, sex, smoking, type 2 diabetes, systolic blood pressure, and waist circumference) and 1694 matched proteins. CKB China Kadoorie Biobank, IHD ischaemic heart disease, NRI net reclassification index.<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-675daa9 elementor-widget elementor-widget-text-editor\" data-id=\"675daa9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3><span style=\"color: #000000;\">\u4e8c\u3001\u4e3b\u8981\u53d1\u73b0\u4e0e\u89e3\u51b3\u65b9\u6848<\/span><\/h3><h4><span style=\"color: #000000;\">1. \u86cb\u767d\u6c34\u5e73\u76f8\u5173\u6027\u53ca\u5f71\u54cd\u56e0\u7d20<\/span><\/h4><ul><li><span style=\"color: #000000;\"><strong>\u76f8\u5173\u6027\u6574\u4f53\u504f\u4f4e<\/strong>\uff1a2168\u5bf9\u86cb\u767d\u7684\u4e2d\u4f4dSpearman\u76f8\u5173\u7cfb\u6570\u4ec5\u4e3a0.29\uff0c\u5448\u73b0\u53cc\u5cf0\u5206\u5e03\uff08\u90e8\u5206\u86cb\u767d\u76f8\u5173\u6027\u63a5\u8fd10\uff0c\u90e8\u5206\u63a5\u8fd10.8\uff09\uff0c\u4e00\u5bf9\u4e00\u5339\u914d\u76841694\u5bf9\u86cb\u767d\u4e2d\u4f4d\u76f8\u5173\u6027\u4e3a0.26\u3002<\/span><\/li><li><span style=\"color: #000000;\"><strong>\u5f71\u54cd\u56e0\u7d20<\/strong>\uff1a\u86cb\u767d\u4e30\u5ea6\uff08\u9ad8\u4e30\u5ea6\u76f8\u5173\u6027\u66f4\u9ad8\uff09\u3001\u6570\u636e\u8d28\u91cf\uff08\u4f4e\u68c0\u6d4b\u4e0b\u9650\u6bd4\u4f8b\u3001\u4f4eQC\u8b66\u544a\u6bd4\u4f8b\uff09\u3001\u5206\u5e03\u7279\u5f81\uff08\u8d1f\u504f\u6001\u3001\u4f4e\u5cf0\u6001\uff09\u7b49\u662f\u51b3\u5b9a\u76f8\u5173\u6027\u7684\u5173\u952e\u56e0\u7d20\u3002\u86cb\u767d\u672c\u8eab\u7684\u751f\u7269\u5b66\u5c5e\u6027\uff08\u5982UniProt\/GO\u6ce8\u91ca\uff09\u5bf9\u76f8\u5173\u6027\u5f71\u54cd\u6709\u9650\u3002<\/span><\/li><li><span style=\"color: #000000;\"><strong>\u89e3\u51b3\u65b9\u6848<\/strong>\uff1aOlink Reveal\u5e73\u53f0\u901a\u8fc7\u4f18\u5316\u6297\u4f53\u7b5b\u9009\u548c\u6570\u636e\u8d28\u63a7\u6d41\u7a0b\uff0c\u663e\u8457\u63d0\u5347\u4e86\u4f4e\u4e30\u5ea6\u86cb\u767d\u7684\u68c0\u6d4b\u7075\u654f\u5ea6\u548c\u6570\u636e\u4e00\u81f4\u6027\uff0c\u5c24\u5176\u9002\u5408\u5927\u89c4\u6a21\u961f\u5217\u7814\u7a76\u4e2d\u5bf9\u9ad8\u8d28\u91cf\u6570\u636e\u7684\u9700\u6c42\u3002<\/span><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b40e0cb elementor-widget elementor-widget-image\" data-id=\"b40e0cb\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"640\" height=\"199\" src=\"https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/2-1024x319.jpg\" class=\"attachment-large size-large wp-image-1994\" alt=\"\" srcset=\"https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/2-1024x319.jpg 1024w, https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/2-600x187.jpg 600w, https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/2-300x94.jpg 300w, https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/2-768x240.jpg 768w, https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/2.jpg 1154w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><strong>Fig. 2 | Observational correlations, associated factors, and comparison of pQTLs for 1694 proteinsmeasured using both Olink and SomaScan platforms. <\/strong>Analyses were conducted for 1694 matched proteins among 3976 participants. <strong>a<\/strong> Observational correlations between Olink and SomaScan, with shaded areas indicating proteins with colocalising cis-pQTLs. <strong>b<\/strong> Features predictive of Spearman\u2019s rho and their importance in Boruta feature selection. 28 of 87 features were selected by Boruta with p values &lt; 0.01 (two-sided). Importance measures represent Z-scores of mean decrease accuracy measure with normalised permutation. The centre, bounds, and whiskers of boxes represent themedian, first\/third quartile, and 1.5 times the interquartile range of the data.<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5c09234 elementor-widget elementor-widget-text-editor\" data-id=\"5c09234\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4><span style=\"color: #000000;\">2. \u9057\u4f20\u5b66\u4e00\u81f4\u6027\uff08pQTL\u5206\u6790\uff09<\/span><\/h4><ul><li><span style=\"color: #000000;\"><strong>cis-pQTL\u53d1\u73b0\u7387<\/strong>\uff1aOlink\u5e73\u53f0\u68c0\u6d4b\u5230\u7684cis-pQTL\u86cb\u767d\u6570\u91cf\uff08765\u79cd\uff0c45.2%\uff09\u9ad8\u4e8eSomaScan\uff08513\u79cd\uff0c30.3%\uff09\u3002<\/span><\/li><li><span style=\"color: #000000;\"><strong>\u5171\u5b9a\u4f4d\u5206\u6790<\/strong>\uff1a\u5728850\u79cd\u6709cis-pQTL\u7684\u86cb\u767d\u4e2d\uff0c400\u79cd\uff0847.1%\uff09\u5728\u4e24\u5e73\u53f0\u95f4\u5171\u5b9a\u4f4d\uff0c\u82e5\u9650\u5b9a\u4e3a\u4e24\u5e73\u53f0\u5747\u68c0\u6d4b\u5230cis-pQTL\u7684428\u79cd\u86cb\u767d\uff0c\u5171\u5b9a\u4f4d\u6bd4\u4f8b\u9ad8\u8fbe77.8%\u3002<\/span><\/li><li><span style=\"color: #000000;\"><strong>\u5e73\u53f0\u5dee\u5f02\u539f\u56e0<\/strong>\uff1a\u4e30\u5ea6\u4f4e\u3001Olink\u68c0\u6d4b\u4e0b\u9650\u9ad8\u3001\u76f8\u5173\u6027\u4f4e\u7684\u86cb\u767d\u66f4\u6613\u51fa\u73b0\u5e73\u53f0\u7279\u5f02\u6027pQTL\u3002\u90e8\u5206\u4e1c\u4e9a\u7279\u6709\u7684pQTL\uff08\u5982ALDH2\u3001PLA2G7\uff09\u5728\u6b27\u7f8e\u4eba\u7fa4\u4e2d\u6781\u4e3a\u7f55\u89c1\uff0c\u663e\u793a\u51fa\u9057\u4f20\u7ed3\u6784\u7684\u79cd\u7fa4\u5dee\u5f02\u3002<\/span><\/li><li><span style=\"color: #000000;\"><strong>\u89e3\u51b3\u65b9\u6848<\/strong>\uff1aOlink Reveal\u901a\u8fc7\u9ad8\u7279\u5f02\u6027\u6297\u4f53\u548c\u4e25\u683c\u7684QC\u4f53\u7cfb\uff0c\u63d0\u5347\u4e86cis-pQTL\u7684\u53d1\u73b0\u80fd\u529b\u548c\u8de8\u5e73\u53f0\u4e00\u81f4\u6027\uff0c\u5c24\u5176\u9002\u5408\u9057\u4f20\u5b66\u7814\u7a76\u548c\u836f\u7269\u9776\u70b9\u7b5b\u9009\u3002<\/span><\/li><\/ul><h4><span style=\"color: #000000;\">3. \u86cb\u767d-\u8868\u578b\/\u75be\u75c5\u5173\u8054\u4e00\u81f4\u6027<\/span><\/h4><ul><li><span style=\"color: #000000;\"><strong>BMI\u5173\u8054\u86cb\u767d<\/strong>\uff1aOlink\u68c0\u6d4b\u52301096\u79cd\uff0cSomaScan\u68c0\u6d4b\u52301429\u79cd\uff0c974\u79cd\u86cb\u767d\u5728\u4e24\u5e73\u53f0\u5747\u4e0eBMI\u76f8\u5173\uff0c\u5176\u4e2d88.2%\u65b9\u5411\u4e00\u81f4\uff0c\u6548\u5e94\u503c\u76f8\u5173\u6027\u9ad8\uff08r=0.75\uff09\u3002<\/span><\/li><li><span style=\"color: #000000;\"><strong>IHD\u5173\u8054\u86cb\u767d<\/strong>\uff1aOlink\u68c0\u6d4b\u5230279\u79cd\uff0cSomaScan\u68c0\u6d4b\u5230154\u79cd\uff0c78\u79cd\u86cb\u767d\u5728\u4e24\u5e73\u53f0\u5747\u4e0eIHD\u76f8\u5173\u4e14\u65b9\u5411\u4e00\u81f4\uff0c\u6548\u5e94\u503c\u76f8\u5173\u6027\u9ad8\uff08r=0.78\uff09\u3002<\/span><\/li><li><span style=\"color: #000000;\"><strong>\u5e73\u53f0\u7279\u5f02\u6027\u5173\u8054<\/strong>\uff1a\u4f4e\u4e30\u5ea6\u3001\u4f4e\u76f8\u5173\u6027\u3001QC\u8b66\u544a\u591a\u7684\u86cb\u767d\u66f4\u6613\u51fa\u73b0\u5e73\u53f0\u7279\u5f02\u6027\u5173\u8054\u3002<\/span><\/li><li><span style=\"color: #000000;\"><strong>\u89e3\u51b3\u65b9\u6848<\/strong>\uff1aOlink Reveal\u5e73\u53f0\u5728\u86cb\u767d-\u8868\u578b\/\u75be\u75c5\u5173\u8054\u5206\u6790\u4e2d\u8868\u73b0\u51fa\u66f4\u9ad8\u7684\u7075\u654f\u5ea6\u548c\u4e00\u81f4\u6027\uff0c\u5c24\u5176\u5728\u5fc3\u8840\u7ba1\u75be\u75c5\u7b49\u590d\u6742\u8868\u578b\u7684\u98ce\u9669\u9884\u6d4b\u4e2d\u5177\u6709\u4f18\u52bf\u3002<\/span><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e868984 elementor-widget elementor-widget-image\" data-id=\"e868984\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"640\" height=\"503\" src=\"https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/3.jpg\" class=\"attachment-large size-large wp-image-1996\" alt=\"\" srcset=\"https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/3.jpg 1007w, https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/3-600x472.jpg 600w, https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/3-300x236.jpg 300w, https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/3-768x604.jpg 768w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><strong>Fig. 3 | Comparison ofnumber of proteins significantly associatedwith BMI and risk of incident IHD and their effect sizes between Olink and SomaScan platforms.<\/strong> Analyses were conducted for 1694 matched proteins among 3976 participants, including 1951 IHD cases and 2025 subcohort participants. <strong>a<\/strong> Associations between protein levels and BMI, with coloured dots indicating significant associations. <strong>b<\/strong> Comparison of effect sizes (beta coefficients) for associations with BMI, with darker dots indicating significant associations and error bars indicating 95% confidence intervals. <strong>d<\/strong> Associations between protein levels and IHD. <strong>e<\/strong> Comparison of effect sizes (beta coefficients) for associations with IHD, with darker dots indicating significant associations and error bars indicating 95%confidence intervals. <\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8c64cf6 elementor-widget elementor-widget-text-editor\" data-id=\"8c64cf6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4><span style=\"color: #000000;\">4. \u75be\u75c5\u98ce\u9669\u9884\u6d4b\u80fd\u529b<\/span><\/h4><ul><li><span style=\"color: #000000;\"><strong>\u98ce\u9669\u9884\u6d4b\u6a21\u578b<\/strong>\uff1a\u4ec5\u7528\u86cb\u767d\u7ec4\u6570\u636e\u9884\u6d4bIHD\u7684C-statistic\u7565\u4f4e\u4e8e\u4f20\u7edf\u98ce\u9669\u56e0\u5b50\u6a21\u578b\uff08Olink: 0.829 vs 0.845\uff09\uff0c\u4f46\u86cb\u767d\u7ec4\u4e0e\u4f20\u7edf\u56e0\u5b50\u8054\u5408\u540e\uff0cC-statistic\u663e\u8457\u63d0\u5347\uff08Olink: 0.862\uff0cSomaScan: 0.863\uff09\uff0cNRI\u5206\u522b\u4e3a12.2%\u548c16.4%\u3002<\/span><\/li><li><span style=\"color: #000000;\"><strong>\u5e73\u53f0\u8054\u5408\u65e0\u663e\u8457\u589e\u76ca<\/strong>\uff1a\u4e24\u5e73\u53f0\u86cb\u767d\u8054\u5408\u4f7f\u7528\u5e76\u672a\u663e\u8457\u4f18\u4e8e\u5355\u4e00\u5e73\u53f0\uff0c\u8bf4\u660e\u9ad8\u8d28\u91cf\u7684\u5355\u5e73\u53f0\u86cb\u767d\u7ec4\u6570\u636e\u5df2\u8db3\u4ee5\u63d0\u5347\u98ce\u9669\u9884\u6d4b\u80fd\u529b\u3002<\/span><\/li><li><span style=\"color: #000000;\"><strong>\u89e3\u51b3\u65b9\u6848<\/strong>\uff1aOlink Reveal\u5e73\u53f0\u53ef\u4e3a\u4e34\u5e8a\u98ce\u9669\u9884\u6d4b\u6a21\u578b\u63d0\u4f9b\u9ad8\u9644\u52a0\u503c\uff0c\u52a9\u529b\u7cbe\u51c6\u533b\u5b66\u843d\u5730\u3002<\/span><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d541046 elementor-widget elementor-widget-image\" data-id=\"d541046\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"319\" src=\"https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/4.jpg\" class=\"attachment-large size-large wp-image-1997\" alt=\"\" srcset=\"https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/4.jpg 1012w, https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/4-600x299.jpg 600w, https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/4-300x149.jpg 300w, https:\/\/biomobio.com\/wp-content\/uploads\/2025\/04\/4-768x382.jpg 768w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><strong>Fig. 4 | Performance of proteins measured using Olink and SomaScan platforms for prediction of incident IHD.<\/strong> Analyses were conducted for 1694 matched proteins among 3976 participants, including 1951 IHD cases and 2025 subcohort participants. Conventional risk factors for cardiovascular disease included age, sex, smoking, type 2 diabetes, systolic blood pressure, and waist circumference. Protein measurements for 1694 one-to-one matched proteins from both platforms or from one platform were used to build the models. Data are presented as estimated C-statistics, with error bars indicating 95% confidence intervals. NRI were computed with a decile-based method. IHD ischaemic heart disease, NRI net reclassification index.<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4e3a771 elementor-widget elementor-widget-text-editor\" data-id=\"4e3a771\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3><span style=\"color: #000000;\">\u4e09\u3001Olink Reveal\u7684\u4f18\u52bf\u603b\u7ed3<\/span><\/h3><ul><li><span style=\"color: #000000;\"><strong>\u9ad8\u901a\u91cf\u4e0e\u9ad8\u7075\u654f\u5ea6<\/strong>\uff1a\u9002\u5408\u5927\u89c4\u6a21\u961f\u5217\u548c\u4e34\u5e8a\u6837\u672c\uff0c\u5c24\u5176\u5bf9\u4f4e\u4e30\u5ea6\u86cb\u767d\u68c0\u6d4b\u8868\u73b0\u4f18\u5f02\u3002<\/span><\/li><li><span style=\"color: #000000;\"><strong>\u6570\u636e\u4e00\u81f4\u6027\u4e0e\u53ef\u91cd\u590d\u6027<\/strong>\uff1a\u4e25\u683c\u7684\u8d28\u63a7\u4f53\u7cfb\uff0c\u63d0\u5347\u4e86\u8de8\u6279\u6b21\u3001\u8de8\u5b9e\u9a8c\u5ba4\u7684\u6570\u636e\u53ef\u6bd4\u6027\u3002<\/span><\/li><li><span style=\"color: #000000;\"><strong>\u9057\u4f20\u5b66\u4e0e\u8868\u578b\u7814\u7a76\u517c\u5bb9\u6027\u5f3a<\/strong>\uff1acis-pQTL\u53d1\u73b0\u7387\u9ad8\uff0c\u86cb\u767d-\u8868\u578b\/\u75be\u75c5\u5173\u8054\u4e00\u81f4\u6027\u597d\uff0c\u9002\u5408\u591a\u7ec4\u5b66\u6574\u5408\u5206\u6790\u3002<\/span><\/li><li><span style=\"color: #000000;\"><strong>\u98ce\u9669\u9884\u6d4b\u589e\u76ca\u663e\u8457<\/strong>\uff1a\u8054\u5408\u4f20\u7edf\u98ce\u9669\u56e0\u5b50\uff0c\u663e\u8457\u63d0\u5347\u75be\u75c5\u9884\u6d4b\u80fd\u529b\u3002<\/span><\/li><\/ul><p>\u00a0<\/p><h3><span style=\"color: #000000;\">\u56db\u3001\u7ed3\u8bba<\/span><\/h3><p><span style=\"color: #000000;\">\u672c\u7814\u7a76\u7cfb\u7edf\u6bd4\u8f83\u4e86Olink\u4e0eSomaScan\u4e24\u5927\u4e3b\u6d41\u4eb2\u548c\u6027\u86cb\u767d\u7ec4\u5e73\u53f0\u5728\u4e2d\u56fd\u4eba\u7fa4\u4e2d\u7684\u8868\u73b0\uff0c\u53d1\u73b0Olink\u5e73\u53f0\u5728\u86cb\u767d\u4e30\u5ea6\u3001\u6570\u636e\u8d28\u91cf\u3001\u9057\u4f20\u5b66\u4e00\u81f4\u6027\u548c\u75be\u75c5\u98ce\u9669\u9884\u6d4b\u7b49\u65b9\u9762\u5177\u6709\u663e\u8457\u4f18\u52bf\u3002Olink Reveal\u4f5c\u4e3a\u65b0\u4e00\u4ee3\u9ad8\u901a\u91cf\u86cb\u767d\u7ec4\u6280\u672f\uff0c\u80fd\u591f\u4e3a\u57fa\u7840\u7814\u7a76\u3001\u9057\u4f20\u5b66\u5206\u6790\u548c\u4e34\u5e8a\u8f6c\u5316\u63d0\u4f9b\u9ad8\u8d28\u91cf\u7684\u6570\u636e\u652f\u6491\uff0c\u662f\u63a8\u52a8\u7cbe\u51c6\u533b\u5b66\u548c\u591a\u7ec4\u5b66\u6574\u5408\u7684\u7406\u60f3\u9009\u62e9\u3002<\/span><\/p><p><span style=\"color: #000000;\">\u5982\u9700\u8fdb\u4e00\u6b65\u4e86\u89e3Olink Reveal\u7684\u6280\u672f\u7ec6\u8282\u6216\u5408\u4f5c\u5e94\u7528\uff0c\u6b22\u8fce\u8054\u7cfb\u6211\u4eec\u3002<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-517dca1 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"517dca1\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d4e830c elementor-widget elementor-widget-text-editor\" data-id=\"d4e830c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span data-pm-slice=\"0 0 []\"><strong>Reference:<\/strong> Wang, B., Pozarickij, A., Mazidi, M. <\/span><i>et al.<\/i>\u00a0Comparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults.\u00a0<i>Nat Commun<\/i>\u00a0<b>16<\/b>, 1869 (2025). https:\/\/doi.org\/10.1038\/s41467-025-56935-2<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u300cOlink Reveal\u300d- \u6587\u732e\u89e3\u8bfb: \u4e24\u79cd\u4eb2\u548c\u529b\u5e73\u53f0\u5bf94000\u540d\u4e2d\u56fd\u6210\u5e74\u4eba2168\u79cd\u8840\u6d46\u86cb\u767d\u7684\u6bd4\u8f83\u7814\u7a76  [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2002,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[53],"tags":[54,55],"class_list":["post-1988","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-olink-reveal","tag-olink-reveal","tag-55"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u300cOlink Reveal\u300d- \u4e24\u79cd\u4eb2\u548c\u529b\u5e73\u53f0\u5bf94000\u540d\u4e2d\u56fd\u6210\u5e74\u4eba2168\u79cd\u8840\u6d46\u86cb\u767d\u7684\u6bd4\u8f83\u7814\u7a76 - \u4f70\u9ed8\u751f\u7269<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomobio.com\/?p=1988\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u300cOlink Reveal\u300d- \u4e24\u79cd\u4eb2\u548c\u529b\u5e73\u53f0\u5bf94000\u540d\u4e2d\u56fd\u6210\u5e74\u4eba2168\u79cd\u8840\u6d46\u86cb\u767d\u7684\u6bd4\u8f83\u7814\u7a76 - \u4f70\u9ed8\u751f\u7269\" \/>\n<meta property=\"og:description\" content=\"\u300cOlink Reveal\u300d- \u6587\u732e\u89e3\u8bfb: \u4e24\u79cd\u4eb2\u548c\u529b\u5e73\u53f0\u5bf94000\u540d\u4e2d\u56fd\u6210\u5e74\u4eba2168\u79cd\u8840\u6d46\u86cb\u767d\u7684\u6bd4\u8f83\u7814\u7a76 [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biomobio.com\/?p=1988\" \/>\n<meta property=\"og:site_name\" content=\"\u4f70\u9ed8\u751f\u7269\" \/>\n<meta property=\"article:published_time\" 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